Crystallization (Comment) | Organism |
---|---|
crystal structure of the enzyme in complex with resveratrol. Crystals of the native QR2 and QR2-resveratrol complex all belong to the P2(1)2(1)2(1) space group | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
resveratrol | the chemopreventive and cardioprotective properties of resveratrol are possibly the results of QR2 activity inhibition, which in turn, up-regulates the expression of cellular antioxidant enzymes and cellular resistance to oxidative stress. All three resveratrol hydroxyl groups form hydrogen bonds with amino acids from QR2, anchoring a flat resveratrol molecule in parallel with the isoalloxazine ring of FAD | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | knockdown K562 cells exhibit increased antioxidant and detoxification enzyme expression and reduced proliferation rates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16083 | recombinant | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
menadione + 1-(2-hydroxyethyl)dihydronicotinamide | - |
Homo sapiens | ? | - |
? | |
additional information | knockdown K562 cells exhibit increased antioxidant and detoxification enzyme expression and reduced proliferation rates | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
QR2 | - |
Homo sapiens |
quinone reductase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
resveratrol | - |
Homo sapiens |